ProArgi-9+, Human Clinical Study (HDHI)

The High Desert Heart Institute 

Human Clinical Study

The most comprehensive human clinical study ever conducted on a nutritional product.

Why this clinical study is important to you.

  1. This is a PRODUCT study. Most clinical studies look at just one item, such as l-arginine to try and isolate and identify what that item does. Few studies investigate a product in this way. The HDHI chose to evaluate ProArgi-9+ as a product, which enables us to compare these results with real world results.
  2. This is a HUMAN clinical study. Many clinical studies involve rats and rabbits instead of humans to test results. It’s important that the HDHI ProArgi-9+ study is a human clinical study.
    Most ARGININE based nutritional products refer to some vague research somewhere for scientific validation of their product. ProArgi-9+ has been tested in this clinical study as well as used in a medical clinic for over four years. No other arginine nutricinal product can say this.

Dr. Siva Arunasalam – Founder and President of the High Desert Heart Institute in Victorville, CA and had this to say about this study:

“I expected a marginal improvement in the symptoms . . . what we ended up seeing was remarkable, positive, remodeling of the heart, positive pulmonary artery changes, pulmonary vascular changes . . . All patients showed a tremendous improvement in many, many objective datapoints that only can be attributed to ProAri-9+.”

Dan Austin, RN – Clinical Coordinator for the Congestive Heart Failure Outpatient Clinic at the High Desert Heart Institute.

Dan Austin was in charge of every patient in this nitric oxide study with ProArgi-9+ Supplements and had this to say about one of the study participants who had congestive heart failure and pulmonary hypertension: “I’ve been doing this type of work in critical care for well over 20 years and you see what congestive heart failure does. I have seen a dramatic, a dramatic reversal in Angelo’s symptoms.”

In 2009, the High Desert Heart Institute began a comprehensive clinical study of ProArgi-9 Plus. HDHI was founded by Dr. Siva Arunasalam, who is an affiliate of Cedars-Sinai of Los Angeles and internationally respected for superior care of high-risk heart patients.
Dr. Siva Arunasalam

This video is an overview of the HDHI ProArgi-9 Plus study.

I expected a marginal improvement in the symptoms…what we ended up seeing was remarkable, positive, remodeling of the heart, positive pulmonary artery changes, pulmonary vascular changes…
Dr. Siva Arunasalam

Dan Austin is the R.N. in charge of every patient in this study.He saw first hand the amazing results of ProArgi-9 Plus from the beginning to the end.

I’ve been doing this type of work in critical care for well over 20 years and you see what congestive heart failure does. I have seen a dramatic, a dramatic reversal in Angelo’s symptoms.”
Dan Austin R.N.

For this study, 33 high-risk heart failure patients were selected. The vast majority of the patients in the study had reached the end of what medical science could do for them. They were at maximum drug levels, maximum supplemental oxygen and maximum therapy. Some of these patients were on a heart-transplant list.

There was nothing else for us to try, we had tried everything with these patients. All patients showed a tremendous improvement in many, many objective data points that only can be attributed to ProArgi-9 Plus. –Dr. Siva Arunasalam

To scientifically measure the effects of ProArgi-9 Plus, every patient received extensive diagnostic testing for 13 weeks producing almost 7000 points of data. Each patient was given two scoops of ProArgi-9 Plus in the morning and two in the evening.

The results of the 90 day study were far more significant than anyone expected. Many of the patients were able to resume normal lives and the quality of life for almost all patients had improved dramatically.

It is important to note that these results are an average of all 33 patients. For instance not all patients had serious problems with peripheral blood flow, but the average of all patients was an increase of 16%.

Most of the patients were able to reduce the number of drugs or the amount of medications they were taking. The figures below are compelling because they reflect dramatic improvement as well as the reduction of medications.

A few of the results were as follows:

  • C-reactive proteins decreased – 25%
  • Triglycerides decreased – 40%
  • Vitamin D levels increased by + 183%
  • Creatinine levels decreased – 11%
  • Pulmonary Hypertension dramatically improved
  • Peripheral blood flow increased to the feet + 16%

(Measured by ankle brachial index)

  • HDL Cholesterol increased + 18%
  • Glucose levels reduced – 8%
  • Magnesium levels increased + 35%

(There is no magnesium in ProArgi9 plus)

  • Albumin decreased by – 70%
  • Bilirubin decreased significantly
  • Systolic BP decreased – 13%
  • Diastolic BP decreased – 17%
  • CASP decreased by – 6%

(Central Aortic Systolic Pressure)

  • Decreases in platelets in the blood
  • Quality of life measurements significantly improved for all participant.


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